Antiviral phospholipids. Anti-HIV drugs conjugated to the glycerobackbone of phospholipids.
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منابع مشابه
Antiviral phospholipids. Anti-HIV drugs conjugated to the glycerobackbone of phospholipids.
Heteroatom fatty acid analogs of myristic acid containing oxygen or sulfur substituted for the alkyl methylene groups inhibit replication of the human immunodeficiency virus (HIV) in infected cells by acting as alternative substrates during the viral protein myristoylation event. In this class of compounds, 12-methoxydodecanoic acid is the most potent compound but is approximately 10(3)-fold le...
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Phosphatidyl glycerol, disphosphatidyl glycerol, and phosphatidyl ethanolamine were found in all of the Thiobacillus species studied. T. thioparus possessed only these phospholipids. T. intermedius, T. neapolitanus, and T. thiooxidans contained phosphatidyl-N-monomethylethanolamine, and T. novellus lipids contained phosphatidyl-N-monomethylethanolamine, phosphatidyl-N-N-dimethylethanolamine, an...
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Anti-phosphatidylglycerol and anti-cardiolipin antisera were prepared in rabbits by using phospholipids purified from Micrococcus lysodeikticus. Anti-phosphatidylglycerol antibodies were found in antisera when either phosphatidylglycerol or cardiolipin were used as immunogens, but adsorption studies indicated they were not similar. Antibodies which reacted with phosphatidylinositol and phosphat...
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T h e dried crystals melted with decomposition a t about 215”. The substance is probably an organic acid but we have not yet had time to examine it thoroughly.” (1) In this modest way inositol seems to have made its first appearance as a lipid constituent. Later in 1930, Anderson and Roberts (2) established the identity of their crystals, obtained from a phospholipid present in avian t...
متن کاملSerum Phospholipids
Serum phospholipid levels were determined in 1,067 healthy persons aged 2 to 77 years. Phospholipid levels increased with age but in a different way for each of the sexes. The age-sex changes of serum phospholipids were similar to those observed for serum cholesterol. Correlation coefficients in members of 156 families indicated that the genetic factor is of importance in determining the serum ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1993
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)53025-8